2008-2-1 · Asparaginase (Elspar) is used in the treatment of acute lymphoblastic leukemia. It depletes plasma asparagine and glutamine, killing leukemic lymphoblasts but also causing immunosuppression. The objective of this work was to assess whether supplementing the diet with glutamine modifies the effect of asparaginase on normal lymphocyte populations ...
Lire la suiteIntroduction. Asparaginase (ASNase) 7 is an effective treatment for acute lymphoblastic leukemia, the most common childhood cancer ().ASNase catalyzes the hydrolysis of amino acid asparagine to aspartic acid and ammonia, exploiting an Achilles heel in the leukemic lymphoblast, low or absent levels of asparagine synthetase (ASNS) ().The potency of the drug to induce cell death is a consequence ...
Lire la suite2014-6-15 · [medical citation needed] While overall survival in this trial is not yet known, response rates at second line were. 91.7% in sensitive disease with median progression-free survival of 5.8 months, and; 33.3% in resistant disease with median progression-free of 3.5 months.
Lire la suite· Introduction. Asparaginase (ASNase) 7 is an effective treatment for acute lymphoblastic leukemia, the most common childhood cancer ().ASNase catalyzes the hydrolysis of amino acid asparagine to aspartic acid and ammonia, exploiting an Achilles heel in the leukemic lymphoblast, low or absent levels of asparagine synthetase (ASNS) ().The potency of the drug to induce cell death is a …
Lire la suite2021-5-8 · [citation needed] In closed plasminogen, access to the activation bond (R561/V562) targeted for cleavage by tPA and uPA is blocked through the position of the KR3/KR4 linker sequence and the O-linked sugar on T346. The position of KR3 may also hinder access to the activation loop. The Inter-domain interactions also block all kringle ligand ...
Lire la suite[citation needed] In closed plasminogen, access to the activation bond (R561/V562) targeted for cleavage by tPA and uPA is blocked through the position of the KR3/KR4 linker sequence and the O-linked sugar on T346. The position of KR3 may also hinder access to the activation loop. The Inter-domain interactions also block all kringle ligand ...
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Lire la suiteF 80 is the mill circuit feed size in micrometers. Rod mill. A rotating drum causes friction and attrition between steel rods and ore particles. [citation needed] But note that the term ''rod mill'' is also used as a synonym for a slitting mill, which makes rods of iron or other metal. Rod mills are …
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Lire la suite2021-10-27 · For information on South Africa''s response to COVID-19 please visit the COVID-19 Corona Virus South African Resource Portal.
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Lire la suiteNo clinical relevant impact was observed on LDL-c and blood pressure, and there was a tendency of BMI reduction in diabetes patients who used telemedicine, but these outcomes should be further explored in future trials.|Citation: Marcolino MS, Maia JX, Alkmim MBM, Boersma E, Ribeiro AL (2013) Telemedicine Application in the Care of Diabetes ...
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Lire la suiteIn July 2021, belumosudil was reported to be in pre-registration phase. Belumosudil (formerly KD025 and SLx-2119) is an experimental drug being explored for the treatment of chronic graft versus host disease (cGvHD), idiopathic pulmonary fibrosis (IPF), and moderate to severe psoriasis.
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Lire la suiteManon des Sources (French pronunciation: [manɔ̃ de suʁs]; meaning Manon of the Spring) is a 1986 French language period tragedy [excessive citations] film. Directed by Claude Berri, it is the second of two films adapted from the 1966 two-volume novel by Marcel Pagnol, who wrote it based on his own earlier film of the same title is the ...
Lire la suite2014-6-15 · [medical citation needed] While overall survival in this trial is not yet known, response rates at second line were. 91.7% in sensitive disease with median progression-free survival of 5.8 months, and; 33.3% in resistant disease with median progression-free of 3.5 months.
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Lire la suite2021-8-3 · Comment faire un enduit extérieur gratte ? La finition grattée. Elle nécessite une taloche garnie de clous appelée gratton. Ce sont les pointes de gratton, courtes ou longues, qui conféreront à l''enduit gratté un effet plus ou moins rugueux. Pour créer l''effet, passez le gratton sur l''enduit en un mouvement circulaire, en ne négligeant aucun espace.
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